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Anti-Actin (E361) Antibody

品牌：Antibodies

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规格：50µl

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Anti-Actin (E361) Antibody

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Overview

Name:	Anti-Actin (E361) Antibody See all Actin primary antibodies
Description:	Rabbit polyclonal antibody to Actin (E361)
Specificity:	Actin (E361) pAb detects endogenous levels of Actin protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids C-terminus of Human Actin.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 45 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.

Target

Function:	Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Involvement in Disease:	Dystonia, juvenile-onset: A form of dystonia with juvenile onset. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. Patients with juvenile-onset dystonia manifest progressive, generalized, dopa-unresponsive dystonia, developmental malformations and sensory hearing loss. Baraitser-Winter syndrome 1: A rare developmental disorder characterized by the combination of congenital ptosis, high-arched eyebrows, hypertelorism, ocular colobomata, and a brain malformation consisting of anterior-predominant lissencephaly. Other typical features include postnatal short stature and microcephaly, intellectual disability, seizures, and hearing loss.
Sequence Similarities:	Belongs to the actin family.
Post-Translational Modification:	ISGylated.
Cellular Location:	Cytoplasm > Cytoskeleton. Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Database Links:	Entrez Gene: 58?Human Entrez Gene: 11459?Mouse Entrez Gene: 29437?Rat Omim: 102610?Human SwissProt: P68133?Human SwissProt: P68134?Mouse SwissProt: P68136?Rat Unigene: 1288?Human Unigene: 214950?Mouse Unigene: 82732?Rat
Synonyms:	a actin Antibody ACTA Antibody ACTA1 Antibody Actin Antibody Actin alpha skeletal muscle Antibody actin, alpha 1, skeletal muscle Antibody actin, alpha 1, skeletal muscle 1 Antibody Actin, alpha skeletal muscle Antibody actina Antibody actine Antibody ACTS_HUMAN Antibody aktin Antibody Alpha Actin 1 Antibody alpha skeletal muscle Antibody Alpha skeletal muscle Actin Antibody alpha-actin Antibody Alpha-actin-1 Antibody ASMA Antibody CFTD Antibody CFTD1 Antibody CFTDM Antibody MPFD Antibody NEM1 Antibody NEM2 Antibody NEM3 Antibody nemaline myopathy type 3 Antibody
Information:	Target information shown above is from the UniProt Consortium.