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Anti-SHMT2 Antibody

品牌：Antibodies

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规格：50µl

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Anti-SHMT2 Antibody

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Name:	Anti-SHMT2 Antibody See all SHMT2 primary antibodies
Description:	Rabbit polyclonal antibody to SHMT2.
Applications:	WB, IHC, IF
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human SHMT2.
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Function:	Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism. Thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA (PubMed:21876188). Interconversion of serine and glycine (PubMed:25619277). Associates with mitochondrial DNA (PubMed:18063578). Plays a role in the deubiquitination of target proteins as component of the BRISC complex (PubMed:24075985). Required for IFNAR1 deubiquitination by the BRISC complex (PubMed:24075985).
Sequence Similarities:	Belongs to the SHMT family.
Cellular Location:	Mitochondrion. Mitochondrion matrix > Mitochondrion nucleoid. Mitochondrion inner membrane. Cytoplasm. Nucleus.
Database Links:	Entrez Gene: 6472?Human Entrez Gene: 108037?Mouse Entrez Gene: 299857?Rat Omim: 138450?Human SwissProt: P34897?Human Unigene: 741179?Human
Synonyms:	Epididymis secretory sperm binding protein Li 51e Antibody GLY A+ Antibody GLYA Antibody glycine auxotroph A, human complement for hamster Antibody Glycine hydroxymethyltransferase Antibody GLYM_HUMAN Antibody HEL S 51e Antibody mitochondrial Antibody Serine hydroxymethyltransferase Antibody Serine hydroxymethyltransferase 2 (mitochondrial) Antibody Serine hydroxymethyltransferase mitochondrial Antibody Serine methylase Antibody SHMT Antibody SHMT 2 Antibody SHMT2 Antibody
Information:	Target information shown above is from the UniProt Consortium.