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Anti-PPP1R8 Antibody

品牌：Antibodies

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规格：50µl

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Anti-PPP1R8 Antibody

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Overview

Name:	Anti-PPP1R8 Antibody See all PPP1R8 primary antibodies
Description:	Rabbit polyclonal antibody to PPP1R8.
Applications:	WB, IHC
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human PPP1R8.
Protein Length:	351 (209)
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation.
Tissue Specificity:	Ubiquitously expressed, with highest levels in heart and skeletal muscle, followed by brain, placenta, lung, liver and pancreas. Less abundant in kidney. The concentration and ratio between isoforms is cell-type dependent. Isoform Alpha (>90%) and isoform Beta were found in brain, heart and kidney. Isoform Gamma is mainly found in B-cells and T-lymphocytes, and has been found in 293 embryonic kidney cells.
Post-Translational Modification:	May be inactivated by phosphorylation on Ser-199 or Ser-204 (By similarity). Phosphorylated by Lyn in vitro on Tyr-264, and also on Tyr-335 in the presence of RNA.
Cellular Location:	Nucleus. Nucleus speckle. Primarily, but not exclusively, nuclear.
Database Links:	Entrez Gene: 5511?Human Entrez Gene: 100336?Mouse Entrez Gene: 313030?Rat Omim: 602636?Human SwissProt: Q12972?Human SwissProt: Q8R3G1?Mouse Unigene: 533474?Human Unigene: 105230?Mouse Unigene: 16580?Rat
Synonyms:	Activator of RNA decay Antibody ARD 1 Antibody ARD-1 Antibody ARD1 Antibody Homolog of E.coli RNase E Antibody NIPP 1 Antibody NIPP-1 Antibody NIPP1 Antibody Nuclear inhibitor of protein phosphatase 1 Antibody nuclear inhibitor of protein phosphatase-1 alpha Antibody Nuclear subunit of PP1 Antibody PP1R8_HUMAN Antibody PPP1R8 Antibody PRO2047 Antibody Protein phosphatase 1 regulatory inhibitor subunit 8 Antibody Protein phosphatase 1 regulatory subunit 8 Antibody RNase E Antibody RNase E, E. coli, homolog of Antibody
Information:	Target information shown above is from the UniProt Consortium.