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Anti-PLK4 Antibody

品牌：Antibodies

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规格：50µl

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Anti-PLK4 Antibody

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Overview

Name:	Anti-PLK4 Antibody See all PLK4 primary antibodies
Description:	Rabbit polyclonal antibody to PLK4.
Applications:	WB
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human PLK4.
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (PubMed:22020124).
Involvement in Disease:	Microcephaly and chorioretinopathy, autosomal recessive, 2: A severe disorder characterized by microcephaly, delayed psychomotor development, growth retardation with dwarfism, and ocular abnormalities.
Sequence Similarities:	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
Post-Translational Modification:	Ubiquitinated; leading to its degradation by the proteasome.
Cellular Location:	Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome > Centriole. Nucleus > Nucleolus. Cleavage furrow. Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles. Associates with centrioles throughout the cell cycle. According to PubMed:16244668, it is not present at cleavage furrows.
Database Links:	Entrez Gene: 10733?Human Entrez Gene: 20873?Mouse Entrez Gene: 310344?Rat SwissProt: O00444?Human SwissProt: Q64702?Mouse SwissProt: B2GUY1?Rat Unigene: 172052?Human Unigene: 3794?Mouse Unigene: 14848?Rat
Synonyms:	PLK 4 Antibody PLK-4 Antibody PLK4 Antibody PLK4_HUMAN Antibody Polo like Kinase 4 Antibody Polo-like kinase 4 Antibody Protein serine/threonine kinase Antibody SAK Antibody Serine/threonine kinase Antibody Serine/Threonine Kinase 18 Antibody Serine/threonine protein kinase 18 Antibody Serine/threonine protein kinase PLK4 Antibody Serine/threonine protein kinase Sak Antibody Serine/threonine-protein kinase 18 Antibody Serine/threonine-protein kinase PLK4 Antibody Serine/threonine-protein kinase SAK Antibody Snk Akin Kinase Antibody STK 18 Antibody STK18 Antibody
Information:	Target information shown above is from the UniProt Consortium.