Anti-Na+/K+-ATPase α1 (Y10) Antibody |产品详情|进口试剂采购网

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Anti-Na+/K+-ATPase α1 (Y10) Antibody

品牌：Antibodies

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规格：50µl

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Anti-Na+/K+-ATPase α1 (Y10) Antibody

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Name:	Anti-Na+/K+-ATPase α1 (Y10) Antibody See all Na+ primary antibodies
Description:	Rabbit polyclonal antibody to Na+/K+-ATPase α1 (Y10)
Specificity:	Na+/K+-ATPase α1 (Y10) pAb detects endogenous levels of A Na+/K+-ATPase α1 protein
Applications:	WB, IHC, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to the N-terminus of Human Na+/K+-ATPase α1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 112 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Function:	This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
Sequence Similarities:	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
Post-Translational Modification:	Phosphorylation on Tyr-10 modulates pumping activity. Phosphorylation of Ser-943 by PKA modulates the response of ATP1A1 to PKC. Dephosphorylation by protein phosphatase 2A (PP2A) following increases in intracellular sodium, leading to increase catalytic activity (By similarity).
Cellular Location:	Cell membrane. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.