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Anti-LRP1 Antibody

品牌：Antibodies

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规格：50µl

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Anti-LRP1 Antibody

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Overview

Name:	Anti-LRP1 Antibody See all LRP1 primary antibodies
Description:	Rabbit monoclonal antibody to LRP1
Specificity:	This antibody detects endogenous levels of LRP1 and does not cross-react with related proteins.
Applications:	WB, ICC/IF, IHC, IP, FC
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant antibody.
Host:	Rabbit
Clonality:	Monoclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 85 kDa
Purity:	Protein A affinity purified
Product Form:	Recombinant Rabbit Monoclonal Antibody. 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

Target

Function:	Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission.
Tissue Specificity:	Most abundant in liver, brain and lung.
Sequence Similarities:	Belongs to the LDLR family.
Post-Translational Modification:	Cleaved into a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515) that remains non-covalently associated. Gamma-secretase-dependent cleavage of LRP-85 releases the intracellular domain from the membrane.
Cellular Location:	Cell membrane. Membrane > Coated pit.
Database Links:	Entrez Gene: 4035?Human Entrez Gene: 16971?Mouse Entrez Gene: 299858?Rat Omim: 107770?Human SwissProt: Q07954?Human SwissProt: Q91ZX7?Mouse Unigene: 162757?Human Unigene: 271854?Mouse Unigene: 22436?Rat
Synonyms:	A2MR Antibody Alpha 2 macroglobulin receptor Antibody alpha 2MR Antibody Alpha-2-macroglobulin receptor Antibody APOER Antibody Apolipoprotein E receptor Antibody APR Antibody CD 91 Antibody CD91 Antibody CD91 antigen Antibody IGFBP3R Antibody LDL receptor related protein 1 Antibody Low density lipoprotein receptor related protein 1 Antibody Low density lipoprotein related protein 1 Antibody Low-density lipoprotein receptor-related protein 1 intracellular domain Antibody LRP Antibody LRP 1 Antibody LRP 515 Antibody LRP 85 Antibody LRP ICD Antibody LRP-1 Antibody LRP-515 Antibody LRP-85 Antibody LRP1 Antibody LRP1 protein Antibody LRP1A Antibody LRP1_HUMAN Antibody LRP515 Antibody LRP85 Antibody LRPICD Antibody MGC88725 Antibody Prolow density lipoprotein receptor related protein 1 Antibody TbetaR V/LRP 1/IGFBP 3 receptor Antibody TbetaRV/LRP1/IGFBP3 receptor Antibody TGFBR 5 Antibody TGFBR5 Antibody Type V tgf beta receptor Antibody
Information:	Target information shown above is from the UniProt Consortium.