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Anti-IRF6 Antibody

品牌：Antibodies

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规格：100µg

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Anti-IRF6 Antibody

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Overview

Name:	Anti-IRF6 Antibody See all IRF6 primary antibodies
Description:	Goat polyclonal antibody to IRF6.
Applications:	ELISA, WB, IHC
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to Human IRF6 (C terminal).
Sequence:	C-TPSMQLPPALPPQ
Host:	Goat
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	100 μg at 0.5 mg/ml.
Product Form:	Liquid
Formulation:	Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development (By similarity). Plays a role in regulating mammary epithelial cell proliferation (By similarity). May regulate WDR65 transcription (By similarity).
Tissue Specificity:	Expressed in normal mammary epithelial cells. Expression is reduced or absent in breast carcinomas.
Involvement in Disease:	Van der Woude syndrome 1: An autosomal dominant developmental disorder characterized by lower lip pits, cleft lip and/or cleft palate. Popliteal pterygium syndrome: An autosomal dominant disorder characterized by oro-facial, skin and genital anomalies. Expressivity is variable. Clinical features include cleft lip/palate, lower lip cysts, syngnathia, congenital ankyloblepharon filiforme in some cases, bifid scrotum, hypoplastic scrotum, hypoplastic uterus, talipes equinovarus. Non-syndromic orofacial cleft 6: A birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum.
Sequence Similarities:	Belongs to the IRF family.
Post-Translational Modification:	Phosphorylated. Phosphorylation status depends on the cell cycle and is a signal for ubiquitination and proteasome-mediated degradation.
Cellular Location:	Nucleus. Cytoplasm. Translocates to nucleus in response to an activating signal.
Database Links:	Entrez Gene: 3664?Human Omim: 607199?Human SwissProt: O14896?Human Unigene: 591415?Human Unigene: 719361?Human
Synonyms:	Interferon regulatory factor 6 Antibody IRF 6 Antibody IRF-6 Antibody IRF6 Antibody IRF6_HUMAN Antibody LPS Antibody OFC 6 Antibody OFC6 Antibody OTTHUMP00000034677 Antibody OTTHUMP00000034678 Antibody PIT Antibody PPS Antibody PPS1 Antibody VWS Antibody VWS1 Antibody
Information:	Target information shown above is from the UniProt Consortium.