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Anti-CD59 Antibody

品牌：Antibodies

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规格：100µg

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Anti-CD59 Antibody

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Target

Function:	Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.
Tissue Specificity:	Highly expressed in T-helper cells. The presence of CD4 is a hallmark of T-helper cells which are specialized in the activation and growth of cytotoxic T-cells, regulation of B cells, or activation of phagocytes. CD4 is also present in other immune cells such as macrophages, dendritic cells or NK cells.
Post-Translational Modification:	Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
Cellular Location:	Cell membrane.
Database Links:	Entrez Gene: 12504 Mouse SwissProt: P06332 Mouse Unigene: 2209 Mouse
Synonyms:	CD 4 Antibody CD4 Antibody CD4 (L3T4) Antibody CD4 antigen Antibody CD4 antigen (p55) Antibody CD4 molecule Antibody CD4 receptor Antibody CD4+ Lymphocyte deficiency, included Antibody CD4mut Antibody CD4_HUMAN Antibody L3T4 Antibody Leu3 Antibody Ly-4 Antibody Lymphocyte antigen CD4 Antibody MGC165891 Antibody OTTHUMP00000238897 Antibody p55 Antibody T cell antigen T4 Antibody T cell antigen T4/LEU3 Antibody T cell differentiation antigen L3T4 Antibody T cell OKT4 deficiency, included Antibody T cell surface antigen T4/Leu 3 Antibody T cell surface antigen T4/Leu3 Antibody T cell surface glycoprotein CD4 Antibody T-cell surface antigen T4/Leu-3 Antibody T-cell surface glycoprotein CD4 Antibody W3/25 Antibody W3/25 antigen Antibody
Information:	Target information shown above is from the UniProt Consortium.