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Anti-CD4 (A429) Antibody

品牌：Antibodies

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规格：50µl

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Anti-CD4 (A429) Antibody

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Overview

Name:	Anti-CD4 (A429) Antibody See all CD4 primary antibodies
Description:	Rabbit polyclonal antibody to CD4 (A429)
Specificity:	CD4 (A429) pAb detects endogenous levels of CD4 protein.
Applications:	WB, IHC, IF
Reactivity:	Human, Mouse
Immunogen:	Synthetic peptide, corresponding to amino acids 391-440 of Human CD4.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 51 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.
Post-Translational Modification:	Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
Cellular Location:	Cell membrane. Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.
Database Links:	Entrez Gene: 920?Human Entrez Gene: 12504?Mouse Omim: 186940?Human SwissProt: P01730?Human SwissProt: P06332?Mouse Unigene: 631659?Human Unigene: 2209?Mouse
Synonyms:	CD 4 Antibody CD4 Antibody CD4 (L3T4) Antibody CD4 antigen Antibody CD4 antigen (p55) Antibody CD4 molecule Antibody CD4 receptor Antibody CD4+ Lymphocyte deficiency, included Antibody CD4mut Antibody CD4_HUMAN Antibody L3T4 Antibody Leu3 Antibody Ly-4 Antibody Lymphocyte antigen CD4 Antibody MGC165891 Antibody OTTHUMP00000238897 Antibody p55 Antibody T cell antigen T4 Antibody T cell antigen T4/LEU3 Antibody T cell differentiation antigen L3T4 Antibody T cell OKT4 deficiency, included Antibody T cell surface antigen T4/Leu 3 Antibody T cell surface antigen T4/Leu3 Antibody T cell surface glycoprotein CD4 Antibody T-cell surface antigen T4/Leu-3 Antibody T-cell surface glycoprotein CD4 Antibody W3/25 Antibody W3/25 antigen Antibody
Information:	Target information shown above is from the UniProt Consortium.