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Anti-CD105 Antibody

品牌：Antibodies

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规格：100T

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Anti-CD105 Antibody

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Name:	Anti-CD105 Antibody See all CD105 primary antibodies
Description:	Mouse monoclonal (MEM-229) antibody to CD105 (FITC).
Specificity:	The antibody MEM-229 recognizes CD105 (Endoglin), a 90 kDa type I integral membrane homodimer glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and ***** bone marrow; it is also present on syncytiotrophoblast on placenta throughout pregnancy.
Applications:	FC, WB, IHC-Fr, ICC
Reactivity:	Human, Porcine
Immunogen:	Recombinant Vaccinia virus containing the human CD105 (L-isoform) cDNA.
Host:	Mouse
Clonality:	Monoclonal
Clone:	MEM-229
Isotype:	IgG2a
Conjugate:	FITC
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline with 15mM Sodium Azide.
Storage:	Store in the dark at 2-8°C. Avoid prolonged exposure to light.

Function:	Major glycoprotein of vascular endothelium. Involved in the regulation of angiogenesis. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade. Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGF-beta1 signaling through SMAD3.
Tissue Specificity:	Endoglin is restricted to endothelial cells in all tissues except bone marrow.
Involvement in Disease:	Telangiectasia, hereditary hemorrhagic, 1: A multisystemic vascular dysplasia leading to dilation of permanent blood vessels and arteriovenous malformations of skin, mucosa, and viscera. The disease is characterized by recurrent epistaxis and gastro-intestinal hemorrhage. Visceral involvement includes arteriovenous malformations of the lung, liver, and brain.
Cellular Location:	Membrane.
Database Links:	Entrez Gene: 2022?Human Omim: 131195?Human SwissProt: P17813?Human Unigene: 76753?Human
Synonyms:	AI528660 Antibody AI662476 Antibody CD 105 Antibody CD105 Antibody CD105 antigen Antibody EGLN_HUMAN Antibody END Antibody Endoglin Antibody Eng Antibody FLJ41744 Antibody HHT1 Antibody ORW Antibody ORW1 Antibody Osler Rendu Weber syndrome 1 Antibody RP11 228B15.2 Antibody S-endoglin Antibody SN6 Antibody
Information:	Target information shown above is from the UniProt Consortium.