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Anti-c-Fos (F3) Antibody

品牌：Antibodies

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规格：50µl

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Anti-c-Fos (F3) Antibody

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Overview

Name:	Anti-c-Fos (F3) Antibody See all c-Fos primary antibodies
Description:	Rabbit polyclonal antibody to c-Fos (F3)
Specificity:	Fos (F3) pAb detects endogenous levels of Fos protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 1-50 of Human c-Fos.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 62 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD- to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.
Sequence Similarities:	Belongs to the bZIP family. Fos subfamily.
Post-Translational Modification:	Phosphorylated in the C-terminal upon stimulation by nerve growth factor (NGF) and epidermal growth factor (EGF). Phosphorylated, in vitro, by MAPK and RSK1. Phosphorylation on both Ser-362 and Ser-374 by MAPK1/2 and RSK1/2 leads to protein stabilization with phosphorylation on Ser-374 being the major site for protein stabilization on NGF stimulation. Phosphorylation on Ser-362 and Ser-374 primes further phosphorylations on Thr-325 and Thr-331 through promoting docking of MAPK to the DEF domain. Phosphorylation on Thr-232, induced by HA-RAS, activates the transcriptional activity and antagonizes sumoylation. Phosphorylation on Ser-362 by RSK2 in osteoblasts contributes to osteoblast transformation (By similarity).
Cellular Location:	Nucleus. Endoplasmic reticulum. Cytoplasm > Cytosol. In quiescent cells, present in very small amounts in the cytosol. Following induction of cell growth, first localizes to the endoplasmic reticulum and only later to the nucleus. Localization at the endoplasmic reticulum requires dephosphorylation at Tyr-10 and Tyr-30.
Database Links:	Entrez Gene: 2353?Human Entrez Gene: 14281?Mouse Entrez Gene: 314322?Rat Omim: 164810?Human SwissProt: P01100?Human SwissProt: P01101?Mouse SwissProt: P12841?Rat Unigene: 246513?Mouse Unigene: 103750?Rat
Synonyms:	Activator protein 1 Antibody AP 1 Antibody C FOS Antibody c-Fos Antibody Cellular oncogene c fos Antibody Cellular oncogene fos Antibody FBJ murine osteosarcoma viral (v fos) oncogene homolog (oncogene FOS) Antibody FBJ murine osteosarcoma viral oncogene homolog Antibody FBJ murine osteosarcoma viral v fos oncogene homolog Antibody FBJ Osteosarcoma Virus Antibody FOS Antibody FOS protein Antibody FOS_HUMAN Antibody G0 G1 switch regulatory protein 7 Antibody G0/G1 switch regulatory protein 7 Antibody G0S7 Antibody Oncogene FOS Antibody p55 Antibody proto oncogene c Fos Antibody Proto oncogene protein c fos Antibody Proto-oncogene c-Fos Antibody v fos FBJ murine osteosarcoma viral oncogene homolog Antibody
Information:	Target information shown above is from the UniProt Consortium.