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Anti-SHP1 Antibody

品牌：Antibodies

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规格：50µl

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Anti-SHP1 Antibody

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Overview

Name:	Anti-SHP1 Antibody See all SHP1 primary antibodies
Description:	Rabbit monoclonal antibody to SHP1
Specificity:	This antibody detects endogenous levels of SHP1 and does not cross-react with related proteins.
Applications:	WB, ICC/IF, IHC, FC
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant antibody.
Host:	Rabbit
Clonality:	Monoclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 68 kDa
Purity:	Protein A affinity purified
Product Form:	Recombinant Rabbit Monoclonal Antibody. 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

Target

Function:	Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.
Tissue Specificity:	Isoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells.
Sequence Similarities:	Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
Post-Translational Modification:	Phosphorylated on tyrosine residues. Binding of KITLG/SCF to KIT increases tyrosine phosphorylation (By similarity). Phosphorylation at Tyr-564 enhances phosphatase activity.
Cellular Location:	Cytoplasm. Nucleus. In neurons, translocates into the nucleus after treatment with angiotensin II (By similarity). Shuttles between the cytoplasm and nucleus via its association with PDPK1.
Database Links:	Entrez Gene: 5777?Human Entrez Gene: 15170?Mouse Entrez Gene: 116689?Rat Omim: 176883?Human SwissProt: P29350?Human SwissProt: P29351?Mouse SwissProt: P81718?Rat Unigene: 63489?Human Unigene: 271799?Mouse Unigene: 18985?Rat
Synonyms:	70Z-SHP Antibody EC 3.1.3.48 Antibody HCP Antibody HCPH Antibody Hematopoietic cell phosphatase Antibody Hematopoietic cell protein tyrosine phosphatase Antibody Hematopoietic cell protein-tyrosine phosphatase Antibody HPTP1C Antibody Protein tyrosine phosphatase 1C Antibody Protein tyrosine phosphatase non receptor type 6 Antibody Protein tyrosine phosphatase SHP1 Antibody Protein-tyrosine phosphatase 1C Antibody protein-tyrosine phosphatase SHP 1 Antibody Protein-tyrosine phosphatase SHP-1 Antibody PTN6_HUMAN Antibody PTP 1C Antibody PTP-1C Antibody PTP1C Antibody Ptpn6 Antibody SH PTP 1 Antibody SH PTP1 Antibody SH-PTP1 Antibody SHP 1 Antibody SHP 1L Antibody SHP1 Antibody SHP1L Antibody tyrosine protein phosphatase non receptor type 6 Antibody Tyrosine-protein phosphatase non-receptor type 6 Antibody
Information:	Target information shown above is from the UniProt Consortium.