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Anti-PRPF3 Antibody

品牌：Antibodies

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规格：50µl

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Anti-PRPF3 Antibody

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Overview

Name:	Anti-PRPF3 Antibody See all PRPF3 primary antibodies
Description:	Rabbit polyclonal antibody to PRPF3.
Applications:	WB, IHC, IF
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human PRPF3.
Protein Length:	683
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome.
Tissue Specificity:	Highly expressed in retina, liver, kidney and blood. Detected at lower levels in heart and brain.
Involvement in Disease:	Retinitis pigmentosa 18: A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
Post-Translational Modification:	Ubiquitinated. Undergoes 'Lys-63'-linked polyubiquitination by PRPF19 and deubiquitination by USP4. 'Lys-63'-linked ubiquitination increases the affinity for PRPF8 and may regulate the assembly of the U4/U6-U5 tri-snRNP complex.
Cellular Location:	Nucleus speckle. Colocalizes with spliceosomal snRNPs.
Database Links:	Entrez Gene: 9129?Human Entrez Gene: 70767?Mouse Entrez Gene: 361995?Rat Omim: 607301?Human SwissProt: O43395?Human SwissProt: Q922U1?Mouse Unigene: 11776?Human Unigene: 279872?Mouse Unigene: 116267?Rat
Synonyms:	hPrp3 Antibody HPRP3P Antibody Pre mRNA splicing factor 3 Antibody Pre-mRNA-splicing factor 3 Antibody Precursor mRNA-processing factor 3, S. crevisiae, homolog of Antibody PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae) Antibody Prp3p Antibody PRPF3 Antibody PRPF3_HUMAN Antibody RP18 Antibody SNRNP90 Antibody U4/U6 small nuclear ribonucleoprotein PRP3 Antibody U4/U6 snRNP 90 kDa protein Antibody
Information:	Target information shown above is from the UniProt Consortium.