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Anti-PRDM1 Antibody

品牌：Antibodies

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规格：100µg

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应用：

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Anti-PRDM1 Antibody

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Overview

Name:	Anti-PRDM1 Antibody See all PRDM1 primary antibodies
Description:	Goat polyclonal antibody to PRDM1.
Applications:	ELISA, WB, IHC
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to Human PRDM1 (C terminal).
Sequence:	C-KVKQETVEPMDP
Host:	Goat
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	100 μg at 0.5 mg/ml.
Product Form:	Liquid
Formulation:	Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection (By similarity). Binds specifically to the PRDI element in the promoter of the beta-interferon gene (PubMed:1851123). Drives the maturation of B-lymphocytes into Ig secreting cells (PubMed:12626569). Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions (By similarity).
Sequence Similarities:	Belongs to the class V-like SAM-binding methyltransferase superfamily.
Post-Translational Modification:	Sumoylation at Lys-816 by PIAS1 augments transcriptional repressor activity, and is critical for plasma cell differentiation.
Cellular Location:	Nucleus. Cytoplasm.
Database Links:	Entrez Gene: 639?Human Omim: 603423?Human SwissProt: O75626?Human Unigene: 436023?Human
Synonyms:	B Lymphocyte Induced Maturation Protein 1 Antibody Beta interferon gene positive regulatory domain I binding factor Antibody Beta-interferon gene positive regulatory domain I-binding factor Antibody BLIMP-1 Antibody BLIMP1 Antibody Positive Regulatory Domain I Binding Factor 1 Antibody Positive regulatory domain I-binding factor 1 Antibody PR Domain Containing 1 Antibody PR domain containing 1 with ZNF domain Antibody PR domain containing 1 with ZNF domain isoform 2 Antibody PR domain containing protein 1 Antibody PR domain zinc finger protein 1 Antibody PR domain-containing protein 1 Antibody PRDI BF1 Antibody PRDI binding factor 1 Antibody PRDI-BF1 Antibody PRDI-binding factor 1 Antibody PRDM 1 Antibody Prdm1 Antibody PRDM1/Blimp1 Antibody PRDM1_HUMAN Antibody
Information:	Target information shown above is from the UniProt Consortium.