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Anti-PELP1 Antibody

品牌：Antibodies

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规格：50µl

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Anti-PELP1 Antibody

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Overview

Name:	Anti-PELP1 Antibody See all PELP1 primary antibodies
Description:	Rabbit polyclonal antibody to PELP1.
Applications:	WB, IHC
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human PELP1.
Protein Length:	1130 (1180)
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Involved in nuclear receptor signaling via its interaction with AR and NR3C1. May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K. Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.
Tissue Specificity:	Widely expressed.
Cellular Location:	Nucleus > Nucleoplasm. Nucleus. Cytoplasm. Mainly found in the nucleoplasm, with low levels detected in the cytoplasm (By similarity). Also found associated with the plasma membrane. Mainly in cytoplasm in a subset of breast tumors. Localization is widely deregulated in endometrial cancers with predominantly cytoplasm localization in high-grade endometrial tumors.
Database Links:	Entrez Gene: 27043?Human Entrez Gene: 75273?Mouse Entrez Gene: 360552?Rat Omim: 609455?Human SwissProt: Q8IZL8?Human SwissProt: Q9DBD5?Mouse SwissProt: Q56B11?Rat Unigene: 513883?Human Unigene: 744899?Human Unigene: 340601?Mouse Unigene: 11628?Rat
Synonyms:	glutamic acid- and leucine-rich protein 1 Antibody HMX3 Antibody MNAR Antibody Modulator of non-genomic activity of estrogen receptor Antibody Modulator of nongenomic activity of estrogen receptor Antibody P160 Antibody PELP1 Antibody PELP1 proline glutamic acid leucine rich protein 1 Antibody PELP1_HUMAN Antibody proline and glutamic acid rich nuclear protein Antibody Proline glutamate and leucine rich protein 1 Antibody Proline- Antibody proline-, glutamic acid- and leucine-rich protein 1 Antibody Transcription factor HMX3 Antibody
Information:	Target information shown above is from the UniProt Consortium.