Anti-ANLN Antibody |产品详情|进口试剂采购网

您好，欢迎来到拜力生物网站！请登录注册

我的订单 | 联系我们 | 在线客服QQ：3012681483 | 客服电话：400-968-7988 | 工作时间：08:30-17:30

主营产品： ELISA试剂盒、抗体、补体血清、兔补体、干扰素、小鼠测温仪、进口试剂、Quidel代理、Swant代理、PBL Assay Science代理

网站首页产品中心代理品牌新闻资讯资源中心关于我们

所在位置：首页 > 产品中心 > Antibodies > Antibodies产品

订购信息

上海拜力生物科技公司

Tel:400-968-7988 021-33779008

Anti-ANLN Antibody

品牌：Antibodies

货号：

规格：100µg

货期：

应用：

咨询客服

立即购买加入购物车

Anti-ANLN Antibody

商品详情参考文献相关资料

Overview

Name:	Anti-ANLN Antibody See all ANLN primary antibodies
Description:	Goat polyclonal antibody to ANLN.
Applications:	ELISA, IHC
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to Human ANLN (C terminal).
Sequence:	WQPDACYKPIGKP
Host:	Goat
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	100 μg at 0.5 mg/ml.
Product Form:	Liquid
Formulation:	Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. May play a significant role in podocyte cell migration (PubMed:24676636).
Tissue Specificity:	Ubiquitously expressed. Present at highest levels in the brain, at high levels in the placenta and testis, at intermediate levels in the intestine, ovary, skeletal muscle and thymus and at lower levels in heart, kidney, liver, lung, pancreas, prostate and spleen. In the kidney, it is widely expressed in tubules, but sparsely expressed in the glomerulus (PubMed:24676636). Expression is significantly increased in renal biopsy specimens from idiopathic FSGS (PubMed:24676636). Overexpressed in many tumor types including breast, colorectal, endometrial, hepatic, kidney, lung, ovarian and pancreatic tumors.
Involvement in Disease:	Focal segmental glomerulosclerosis 8: A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and progressive decline in renal function. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation.
Post-Translational Modification:	Phosphorylated during mitosis.
Cellular Location:	Nucleus. Cytoplasm > Cytoskeleton. Cytoplasm > Cell cortex. Mainly found in the nucleus during interphase. Colocalizes with cortical F-actin upon nuclear envelope breakdown in mitosis and subsequently concentrates in the area of the prospective contractile ring in anaphase. This pattern persists until telophase, when the protein becomes concentrated in the midbody.
Database Links:	Entrez Gene: 54443?Human Omim: 616027?Human SwissProt: Q9NQW6?Human Unigene: 62180?Human
Synonyms:	Actin binding protein anillin Antibody Actin binding protein scraps homolog Drosophila Antibody Actin-binding protein anillin Antibody Anillin Antibody Anillin actin binding protein Antibody anln Antibody ANLN_HUMAN Antibody DKFZp779A055 Antibody FSGS8 Antibody Scra Antibody Scraps Antibody Scraps homolog Antibody
Information:	Target information shown above is from the UniProt Consortium.