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Anti-TRIM63 Antibody

品牌：Antibodies

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规格：100µg

货期：

应用：

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Anti-TRIM63 Antibody

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Overview

Name:	Anti-TRIM63 Antibody See all TRIM63 primary antibodies
Description:	Goat polyclonal antibody to TRIM63.
Applications:	ELISA, IHC
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to Human TRIM63 (N terminal).
Sequence:	DYKSSLIQDGNPM-C
Host:	Goat
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	100 μg at 0.5 mg/ml.
Product Form:	Liquid
Formulation:	Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.
Tissue Specificity:	Muscle specific. Selectively expressed in heart and skeletal muscle. Also expressed in the iris.
Cellular Location:	Cytoplasm. Nucleus. Cytoplasm > Myofibril > Sarcomere > M line. Cytoplasm > Myofibril > Sarcomere > Z line. Colocalizes with TNNI3 in myocytes (By similarity). Localizes to the M- and Z-lines in skeletal muscle.
Database Links:	Entrez Gene: 84676?Human Omim: 606131?Human SwissProt: Q969Q1?Human Unigene: 279709?Human
Synonyms:	E3 ubiquitin-protein ligase TRIM63 Antibody FLJ32380 Antibody IRF Antibody Iris RING finger protein Antibody MURF 1 Antibody MURF-1 Antibody MURF1 Antibody MURF2 Antibody Muscle specific ring finger protein 1 Antibody Muscle specific ring finger protein 2 Antibody Muscle-specific RING finger protein 1 Antibody OTTHUMP00000008701 Antibody RING finger protein 28 Antibody RNF 28 Antibody RNF28 Antibody SMRZ Antibody Striated muscle RING zinc finger protein Antibody TRI63_HUMAN Antibody TRIM 63 Antibody Trim63 Antibody Tripartite motif containing 63 Antibody tripartite motif containing 63, E3 ubiquitin protein ligase Antibody Tripartite motif containing protein 63 Antibody Tripartite motif-containing protein 63 Antibody Ubiquitin ligase TRIM63 Antibody
Information:	Target information shown above is from the UniProt Consortium.