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Anti-IRS-1 (phospho-S307) Antibody

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规格：50µl

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Anti-IRS-1 (phospho-S307) Antibody

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Overview

Name:	Anti-IRS-1 (phospho-S307) Antibody See all IRS-1 primary antibodies
Description:	Rabbit polyclonal antibody to IRS-1 (phospho-S307)
Specificity:	P-IRS-1 (S307) pAb detects endogenous levels of IRS-1 protein only when phosphorylated at Ser307
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic phosphopeptide derived from human IRS-1 around the phosphorylation site of Serine 307.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~132, 180 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).
Involvement in Disease:	Diabetes mellitus, non-insulin-dependent: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
Post-Translational Modification:	Serine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-312 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor (By similarity). Phosphorylation of Tyr-896 is required for GRB2-binding (By similarity). Phosphorylated by ALK. Phosphorylated at Ser-270, Ser-307, Ser-636 and Ser-1101 by RPS6KB1; phosphorylation induces accelerated degradation of IRS1.
Database Links:	Entrez Gene: 3667?Human Entrez Gene: 16367?Mouse Entrez Gene: 25467?Rat Omim: 147545?Human SwissProt: P35568?Human SwissProt: P35569?Mouse SwissProt: P35570?Rat Unigene: 471508?Human Unigene: 4952?Mouse Unigene: 10476?Rat
Synonyms:	HIRS 1 Antibody HIRS1 Antibody Insulin receptor substrate 1 Antibody IRS 1 Antibody IRS-1 Antibody IRS1 Antibody IRS1_HUMAN Antibody OTTHUMP00000164234 Antibody
Information:	Target information shown above is from the UniProt Consortium.