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Anti-HNRNPA2B1 Antibody

品牌：Antibodies

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规格：50µl

货期：

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Anti-HNRNPA2B1 Antibody

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Overview

Name:	Anti-HNRNPA2B1 Antibody See all HNRNPA2B1 primary antibodies
Description:	Rabbit polyclonal antibody to HNRNPA2B1.
Applications:	WB, IHC, IF
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human HNRNPA2B1.
Protein Length:	353 (341)
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs (PubMed:19099192). Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (PubMed:10567417). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts (PubMed:26321680). Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs (PubMed:24356509). Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (PubMed:26321680).
Involvement in Disease:	Inclusion body myopathy with early-onset Paget disease with or without frontotemporal dementia 2: An autosomal dominant disease characterized by disabling muscle weakness clinically resembling to limb girdle muscular dystrophy, osteolytic bone lesions consistent with Paget disease, and premature frontotemporal dementia. Clinical features show incomplete penetrance.
Post-Translational Modification:	Sumoylated in exosomes, promoting miRNAs-binding.
Cellular Location:	Nucleus > Nucleoplasm. Cytoplasmic granule. Secreted > Exosome. Localized in cytoplasmic mRNP granules containing untranslated mRNAs (PubMed:17289661). Component of ribonucleosomes (PubMed:17289661). Not found in the nucleolus (PubMed:17289661). Found in exosomes follwong sumoylation (PubMed:24356509).
Database Links:	Entrez Gene: 3181?Human Entrez Gene: 100045191?Mouse Entrez Gene: 53379?Mouse Entrez Gene: 362361?Rat Omim: 600124?Human SwissProt: P22626?Human SwissProt: O88569?Mouse SwissProt: A7VJC2?Rat Unigene: 487774?Human Unigene: 155896?Mouse Unigene: 4057?Rat
Synonyms:	Heterogeneous nuclear ribonucleoprotein A2 Antibody Heterogeneous nuclear ribonucleoprotein A2/B1 Antibody Heterogeneous nuclear ribonucleoprotein B1 Antibody Heterogeneous nuclear ribonucleoproteins A2/B1 Antibody hnRNP A2 Antibody hnRNP A2 / hnRNP B1 Antibody hnRNP A2/B1 Antibody hnRNP A2B1 Antibody hnRNP B1 Antibody hnRNP-A2 Antibody hnRNP-B1 Antibody hnRNPA2 Antibody Hnrnpa2b1 Antibody hnRNPB1 Antibody HNRPA2 Antibody HNRPA2B1 Antibody HNRPB1 Antibody Nuclear ribonucleoprotein particle A2 protein Antibody RNP A2 Antibody RNP B1 Antibody RNP-A2 Antibody RNP-B1 Antibody RNPA2 Antibody RNPB1 Antibody ROA2_HUMAN Antibody SNRPB1 Antibody
Information:	Target information shown above is from the UniProt Consortium.