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Anti-Beta Tubulin Antibody

品牌：Antibodies

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规格：100µl

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Anti-Beta Tubulin Antibody

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Overview

Name:	Anti-Beta Tubulin Antibody See all Beta Tubulin primary antibodies
Description:	Rabbit monoclonal antibody to beta Tubulin.
Applications:	WB, IHC, IF, FC
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, ICC: 1:50 - 1:200, IF: 1:50 - 1:200, FC: 1:10 - 1:50.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human TUBB.
Host:	Rabbit
Clonality:	Monoclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
Tissue Specificity:	Ubiquitously expressed with highest levels in spleen, thymus and immature brain.
Involvement in Disease:	Cortical dysplasia, complex, with other brain malformations 6: A disorder of aberrant neuronal migration and disturbed axonal guidance. Affected individuals have microcephaly, ataxia, and severe delayed psychomotor development. Brain imaging shows variable malformations of cortical development, including white matter streaks, dysmorphic basal ganglia, corpus callosum abnormalities, brainstem and cerebellar hypoplasia, cortical dysplasia, polymicrogyria. Skin creases, congenital symmetric circumferential, 1: An autosomal dominant disease characterized by multiple, symmetric, circumferential rings of folded skin, affecting primarily the limbs. Affected individuals also exhibit intellectual disability, cleft palate, and dysmorphic features.
Sequence Similarities:	Belongs to the tubulin family.
Post-Translational Modification:	Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (PubMed:26875866). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (PubMed:26875866).
Cellular Location:	Cytoplasm > Cytoskeleton.
Database Links:	Entrez Gene: 203068?Human Entrez Gene: 22154?Mouse Entrez Gene: 29214?Rat Omim: 191130?Human SwissProt: P07437?Human SwissProt: P99024?Mouse SwissProt: P69897?Rat Unigene: 636480?Human
Synonyms:	Beta 4 tubulin Antibody Beta 5 tubulin Antibody beta Ib tubulin Antibody beta Tubulin Antibody Beta1 tubulin Antibody Class I beta tubulin Antibody M40 Antibody MGC117247 Antibody MGC16435 Antibody OK/SW cl.56 Antibody OK/SWcl.56 Antibody TBB5_HUMAN Antibody TUBB Antibody TUBB 1 Antibody TUBB 2 Antibody TUBB 5 Antibody TUBB1 Antibody TUBB2 Antibody TUBB5 Antibody tubulin beta 1 chain Antibody Tubulin beta 2 chain Antibody tubulin beta 5 chain Antibody Tubulin beta chain Antibody Tubulin beta class I Antibody tubulin beta polypeptide Antibody Tubulin beta-5 chain Antibody
Information:	Target information shown above is from the UniProt Consortium.