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Anti-SOCS1 Antibody

品牌：Antibodies

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规格：100µg

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Anti-SOCS1 Antibody

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Overview

Name:	Anti-SOCS1 Antibody See all SOCS1 primary antibodies
Description:	Goat polyclonal antibody to SOCS1.
Applications:	ELISA, WB
Reactivity:	Mouse, Human
Immunogen:	Synthetic peptide corresponding to Human SOCS1 (C terminal).
Sequence:	C-VLRDYLSSFPFQI
Host:	Goat
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	100 µg at 0.5 mg/ml.
Product Form:	Liquid
Formulation:	Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity (By similarity). Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2 (By similarity). SOCS1 appears to be a negative regulator in IGF1R signaling pathway (By similarity).
Tissue Specificity:	High expression in thymus. Lower expression in lung and spleen. Expressed in both Th1 and Th2 cells.
Sequence Similarities:	Belongs to the SOCS1 family.
Cellular Location:	Nucleus. Cytoplasmic vesicle. Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3.
Database Links:	Entrez Gene: 8651 Human Entrez Gene: 12703 Mouse Omim: 603597 Human SwissProt: O15524 Human SwissProt: O35716 Mouse Unigene: 50640 Human Unigene: 130 Mouse
Synonyms:	CISH 1 Antibody CISH1 Antibody Cytokine inducible SH2 protein 1 Antibody JAB Antibody JAK binding protein Antibody JAK-binding protein Antibody Janus kinase binding protein Antibody SOCS 1 Antibody SOCS-1 Antibody SOCS1 Antibody SOCS1_HUMAN Antibody SSI 1 Antibody SSI-1 Antibody SSI1 Antibody STAT induced STAT inhibitor 1 Antibody STAT-induced STAT inhibitor 1 Antibody Suppressor of cytokine signaling 1 Antibody Supressor of cytokine signalling 1 Antibody TEC interacting protein 3 Antibody Tec-interacting protein 3 Antibody TIP 3 Antibody TIP-3 Antibody TIP3 Antibody
Information:	Target information shown above is from the UniProt Consortium.