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Anti-Cyclin D1 Antibody

品牌：Antibodies

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规格：50µl

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Anti-Cyclin D1 Antibody

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Overview

Name:	Anti-Cyclin D1 Antibody See all Cyclin D1 primary antibodies
Description:	Rabbit polyclonal antibody to Cyclin D1
Specificity:	Cyclin D1 pAb detects endogenous levels of Cyclin D1 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant full length Human Cyclin D1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 36 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.

Target

Function:	Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner.
Involvement in Disease:	Multiple myeloma: A malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia.
Sequence Similarities:	Belongs to the cyclin family. Cyclin D subfamily.
Post-Translational Modification:	Phosphorylation at Thr-286 by MAP kinases is required for ubiquitination and degradation following DNA damage. It probably plays an essential role for recognition by the FBXO31 component of SCF (SKP1-cullin-F-box) protein ligase complex.
Cellular Location:	Nucleus. Cytoplasm. Membrane. Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members.
Database Links:	Entrez Gene: 595?Human Entrez Gene: 12443?Mouse Entrez Gene: 58919?Rat Omim: 168461?Human SwissProt: P24385?Human SwissProt: P25322?Mouse SwissProt: P39948?Rat Unigene: 523852?Human Unigene: 667996?Human Unigene: 273049?Mouse Unigene: 22279?Rat
Synonyms:	AI327039 Antibody B cell CLL/lymphoma 1 Antibody B cell leukemia 1 Antibody B cell lymphoma 1 protein Antibody B-cell lymphoma 1 protein Antibody BCL 1 Antibody BCL-1 Antibody BCL-1 oncogene Antibody BCL1 Antibody BCL1 oncogene Antibody ccnd1 Antibody CCND1/FSTL3 fusion gene, included Antibody CCND1/IGHG1 fusion gene, included Antibody CCND1/IGLC1 fusion gene, included Antibody CCND1/PTH fusion gene, included Antibody CCND1_HUMAN Antibody cD1 Antibody Cyclin D1 Antibody Cyl 1 Antibody D11S287E Antibody G1/S specific cyclin D1 Antibody G1/S-specific cyclin-D1 Antibody Parathyroid adenomatosis 1 Antibody PRAD1 Antibody PRAD1 oncogene Antibody U21B31 Antibody
Information:	Target information shown above is from the UniProt Consortium.