Anti-RUNX-2 (D198) Antibody |产品详情|进口试剂采购网

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Anti-RUNX-2 (D198) Antibody

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规格：50µl

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Anti-RUNX-2 (D198) Antibody

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Overview

Name:	Anti-RUNX-2 (D198) Antibody See all RUNX2 primary antibodies
Description:	Rabbit polyclonal antibody to RUNX-2 (D198)
Specificity:	RUNX-2 (D198) pAb detects endogenous levels of RUNX-2 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 166-220 of Human RUNX-2.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 57 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation.
Tissue Specificity:	Specifically expressed in osteoblasts.
Involvement in Disease:	Cleidocranial dysplasia: Autosomal dominant skeletal disorder with high penetrance and variable expressivity. It is due to defective endochondral and intramembranous bone formation. Typical features include hypoplasia/aplasia of clavicles, patent fontanelles, wormian bones (additional cranial plates caused by abnormal ossification of the calvaria), supernumerary teeth, short stature, and other skeletal changes. In some cases defects in RUNX2 are exclusively associated with dental anomalies. Metaphyseal dysplasia with maxillary hypoplasia with or without brachydactyly: An autosomal dominant bone dysplasia characterized by metaphyseal flaring of long bones, enlargement of the medial halves of the clavicles, maxillary hypoplasia, variable brachydactyly, and dystrophic teeth.
Post-Translational Modification:	Phosphorylated; probably by MAP kinases (MAPK). Phosphorylation by HIPK3 is required for the SPEN/MINT and FGF2 transactivation during osteoblastic differentiation (By similarity). Phosphorylation at Ser-451 by CDK1 promotes endothelial cell proliferation required for tumor angiogenesis probably by facilitating cell cycle progression. Isoform 3 is phosphorylated on Ser-340.
Cellular Location:	Nucleus.
Database Links:	Entrez Gene: 860?Human Entrez Gene: 12393?Mouse Entrez Gene: 367218?Rat Omim: 600211?Human SwissProt: Q13950?Human SwissProt: Q08775?Mouse SwissProt: Q9Z2J9?Rat Unigene: 535845?Human Unigene: 391013?Mouse Unigene: 391017?Mouse Unigene: 214214?Rat Unigene: 83672?Rat
Synonyms:	Acute myeloid leukemia 3 protein Antibody Alpha subunit 1 Antibody AML3 Antibody CBF alpha 1 Antibody CBF-alpha-1 Antibody CBFA1 Antibody CCD Antibody CCD1 Antibody Cleidocranial dysplasia 1 Antibody Core binding factor Antibody Core binding factor runt domain alpha subunit 1 Antibody Core binding factor subunit alpha 1 Antibody Core-binding factor subunit alpha-1 Antibody MGC120022 Antibody MGC120023 Antibody Oncogene AML 3 Antibody Oncogene AML-3 Antibody OSF 2 Antibody OSF-2 Antibody OSF2 Antibody Osteoblast specific transcription factor 2 Antibody Osteoblast-specific transcription factor 2 Antibody OTTHUMP00000016533 Antibody PEA2 alpha A Antibody PEA2-alpha A Antibody PEA2aA Antibody PEBP2 alpha A Antibody PEBP2-alpha A Antibody PEBP2A1 Antibody PEBP2A2 Antibody PEBP2aA Antibody PEBP2aA1 Antibody Polyomavirus enhancer binding protein 2 alpha A subunit Antibody Polyomavirus enhancer-binding protein 2 alpha A subunit Antibody Runt domain Antibody Runt related transcription factor 2 Antibody Runt-related transcription factor 2 Antibody RUNX2 Antibody RUNX2_HUMAN Antibody SL3 3 enhancer factor 1 alpha A subunit Antibody SL3-3 enhancer factor 1 alpha A subunit Antibody SL3/AKV core binding factor alpha A subunit Antibody SL3/AKV core-binding factor alpha A subunit Antibody
Information:	Target information shown above is from the UniProt Consortium.