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Anti-DCTN1 Antibody

品牌：Antibodies

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规格：100µg

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Anti-DCTN1 Antibody

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Overview

Name:	Anti-DCTN1 Antibody See all DCTN1 primary antibodies
Description:	Goat polyclonal antibody to DCTN1.
Applications:	ELISA, WB, IHC, ICC
Reactivity:	Human, Mouse
Immunogen:	Synthetic peptide corresponding to Human DCTN1 (C terminal).
Sequence:	C-QEQLHQLHSRLIS
Host:	Goat
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	100 μg at 0.5 mg/ml.
Product Form:	Liquid
Formulation:	Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule. Can regulate microtubule stability by promoting microtubule formation, nucleation and polymerization and by inhibiting microtubule catastrophe in neurons. Inhibits microtubule catastrophe by binding both to microtubules and to tubulin, leading to enhanced microtubule stability along the axon. Plays a role in metaphase spindle orientation. Plays a role in centriole cohesion and subdistal appendage organization and function. Its recruitement to the centriole in a KIF3A-dependent manner is essential for the maintenance of centriole cohesion and the formation of subdistal appendage. Also required for microtubule anchoring at the mother centriole. Plays a role in primary cilia formation.
Sequence Similarities:	Belongs to the dynactin 150 kDa subunit family.
Post-Translational Modification:	Ubiquitinated by a SCF complex containing FBXL5, leading to its degradation by the proteasome.
Cellular Location:	Cytoplasm. Cytoplasm > Cytoskeleton. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome > Centriole. Cytoplasm > Cytoskeleton > Spindle. Nucleus envelope. Cytoplasm > Cell cortex. Localizes to microtubule plus ends. Localizes preferentially to the ends of tyrosinated microtubules (PubMed:16954346). Localization at centrosome is regulated by SLK-dependent phosphorylation. Localizes to centrosome in a PARKDA-dependent manner. PLK1-mediated phosphorylation at Ser-179 is essential for its localization in the nuclear envelope (By similarity). Localizes to the subdistal appendage region of the centriole in a KIF3A-dependent manner (PubMed:23386061).
Database Links:	Entrez Gene: 1639?Human Entrez Gene: 13191?Mouse Omim: 601143?Human SwissProt: Q14203?Human SwissProt: O08788?Mouse Unigene: 516111?Human Unigene: 6919?Mouse
Synonyms:	150 kDa dynein associated polypeptide Antibody 150 kDa dynein-associated polypeptide Antibody DAP 150 Antibody DAP-150 Antibody DAP150 Antibody DCTN 1 Antibody DCTN1 Antibody DCTN1_HUMAN Antibody DP 150 Antibody DP-150 Antibody DP150 Antibody Dynactin 1 Antibody Dynactin 1 (p150 Glued (Drosophila) homolog) Antibody Dynactin 1 (p150 glued homolog Drosophila) Antibody Dynactin subunit 1 Antibody Dynactin1 Antibody HMN7B Antibody p135 Antibody p150 glued Antibody p150 Glued (Drosophila) homolog Antibody p150 glued homolog Antibody p150(GLUED) DROSOPHILA HOMOLOG OF Antibody p150-glued Antibody p150glued Antibody
Information:	Target information shown above is from the UniProt Consortium.