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Anti-Caspase 9 (Tyr153) Antibody

品牌：Antibodies

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规格：50µl

货期：

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Anti-Caspase 9 (Tyr153) Antibody

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Name:	Anti-Caspase 9 (Tyr153) Antibody See all Caspase 9 primary antibodies
Description:	Rabbit polyclonal antibody to Caspase 9 (Tyr153)
Specificity:	Caspase 9 (Tyr153) pAb detects endogenous levels of full length caspase-9 (48 kDa) and large fragments of caspase-9 (35 kDa).
Applications:	WB
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 130-180 of Human Caspase 9.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 35,48 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.

Function:	Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).
Tissue Specificity:	Ubiquitous, with highest expression in the heart, moderate expression in liver, skeletal muscle, and pancreas. Low levels in all other tissues. Within the heart, specifically expressed in myocytes.
Sequence Similarities:	Belongs to the peptidase C14A family.
Post-Translational Modification:	Cleavages at Asp-315 by granzyme B and at Asp-330 by caspase-3 generate the two active subunits. Caspase-8 and -10 can also be involved in these processing events.
Synonyms:	APAF3 Antibody CASP9 Antibody Caspase 9 Antibody ICE LAP6 Antibody MCH6 Antibody
Information:	Target information shown above is from the UniProt Consortium.