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Anti-NOS2 (V1131) Antibody

品牌：Antibodies

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规格：50µl

货期：

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Anti-NOS2 (V1131) Antibody

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Name:	Anti-NOS2 (V1131) Antibody See all NOS2 primary antibodies
Description:	Rabbit polyclonal antibody to NOS2 (V1131)
Specificity:	NOS2 (V1131) pAb detects endogenous levels of Inducible NOS protein.
Applications:	WB, IHC, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids C-terminus of Human NOS2.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 130 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Function:	Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed:7531687, PubMed:7544004). In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (By similarity). As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM (PubMed:25417112). Involved in inflammation, enhances the synthesis of proinflammatory mediators such as IL6 and IL8 (PubMed:19688109).
Tissue Specificity:	Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not expressed in the platelets.
Sequence Similarities:	Belongs to the NOS family.