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Anti-Histone H3 (K4) Antibody

品牌：Antibodies

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规格：50µl

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Anti-Histone H3 (K4) Antibody

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Overview

Name:	Anti-Histone H3 (K4) Antibody See all Histone H3 primary antibodies
Description:	Rabbit polyclonal antibody to Histone H3 (K4)
Specificity:	Histone H3 (K4) pAb detects endogenous levels of Histone H3 protein.
Applications:	WB, IHC, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to the N-terminal of Human Histone H3.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 17 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Sequence Similarities:	Belongs to the histone H3 family.
Post-Translational Modification:	Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability.
Cellular Location:	Nucleus. Chromosome.
Database Links:	Entrez Gene: 10338?Human Entrez Gene: 3020?Human Entrez Gene: 3021?Human Entrez Gene: 8290?Human Entrez Gene: 8350?Human Entrez Gene: 8351?Human Entrez Gene: 8352?Human Entrez Gene: 8353?Human Entrez Gene: 8354?Human Entrez Gene: 8355?Human Entrez Gene: 8356?Human Entrez Gene: 8357?Human Entrez Gene: 8358?Human Entrez Gene: 8968?Human Entrez Gene: 15078?Mouse Entrez Gene: 15079?Mouse Entrez Gene: 15080?Mouse Entrez Gene: 15081?Mouse Entrez Gene: 260423?Mouse Entrez Gene: 319148?Mouse Entrez Gene: 319149?Mouse Entrez Gene: 319150?Mouse Entrez Gene: 319151?Mouse Entrez Gene: 319152?Mouse Entrez Gene: 319153?Mouse Entrez Gene: 360198?Mouse Entrez Gene: 97908?Mouse Entrez Gene: 100361558?Rat Entrez Gene: 100364501?Rat Entrez Gene: 100365096?Rat Entrez Gene: 100365669?Rat Entrez Gene: 117056?Rat Entrez Gene: 289314?Rat Entrez Gene: 291159?Rat Entrez Gene: 314977?Rat Entrez Gene: 364716?Rat Entrez Gene: 679950?Rat Entrez Gene: 679994?Rat Entrez Gene: 680511?Rat Entrez Gene: 680599?Rat Entrez Gene: 682330?Rat Entrez Gene: 691496?Rat Omim: 601058?Human Omim: 601128?Human Omim: 602810?Human Omim: 602811?Human Omim: 602812?Human Omim: 602813?Human Omim: 602814?Human Omim: 602815?Human Omim: 602816?Human Omim: 602817?Human Omim: 602818?Human Omim: 602819?Human SwissProt: P06351?Human SwissProt: P16106?Human SwissProt: P68431?Human SwissProt: P84243?Human SwissProt: Q16695?Human SwissProt: Q6NXT2?Human SwissProt: Q71DI3?Human SwissProt: Q93081?Human SwissProt: P16105?Mouse SwissProt: P68433?Mouse SwissProt: P84228?Mouse SwissProt: P84244?Mouse SwissProt: B0BMY8?Rat SwissProt: P06351?Rat SwissProt: P84245?Rat SwissProt: Q6LED0?Rat Unigene: 132854?Human Unigene: 180877?Human Unigene: 181307?Human Unigene: 247813?Human Unigene: 247814?Human Unigene: 248171?Human Unigene: 248176?Human Unigene: 443021?Human Unigene: 484990?Human Unigene: 532144?Human Unigene: 533292?Human Unigene: 533624?Human Unigene: 546315?Human Unigene: 586261?Human Unigene: 591778?Human Unigene: 626666?Human Unigene: 726012?Human Unigene: 138832?Mouse Unigene: 18516?Mouse Unigene: 221301?Mouse Unigene: 221389?Mouse Unigene: 261657?Mouse Unigene: 261658?Mouse Unigene: 262517?Mouse Unigene: 315189?Mouse Unigene: 316825?Mouse Unigene: 322735?Mouse Unigene: 347699?Mouse Unigene: 371563?Mouse Unigene: 377874?Mouse Unigene: 390558?Mouse Unigene: 397328?Mouse Unigene: 442502?Mouse Unigene: 106155?Rat Unigene: 124815?Rat Unigene: 138090?Rat Unigene: 198918?Rat Unigene: 230771?Rat Unigene: 29857?Rat
Synonyms:	H3.3A Antibody HIST1 cluster, H3E Antibody HIST1 cluster, H3J Antibody Histone gene cluster 1, H3 histone family, member E Antibody Histone gene cluster 1, H3G Antibody H3 histone family, member A Antibody H3 histone family, member J Antibody H3.1 Antibody H3/l Antibody H3F3 Antibody H3FF Antibody H3FJ Antibody H3FL Antibody HIST1 cluster, H3E Antibody HIST1 cluster, H3I Antibody Histone gene cluster 1, H3 histone family, member E Antibody Histone gene cluster 1, H3C Antibody histone H3.1t Antibody Histone H3/o Antibody Cit Histone H3 Antibody Citrullated Antibody citrullin Antibody Citrullinated Histone H3 Antibody citrulline Antibody FLJ92264 Antibody H 3 Antibody H3 Antibody H3 3 like sequence MH921 Antibody H3 3A Antibody H3 a Antibody H3 b Antibody H3 c Antibody H3 d Antibody H3 f Antibody H3 h Antibody H3 histone Antibody H3 histone family member E pseudogene Antibody H3 histone family, member A Antibody H3 histone family, member B Antibody H3 histone family, member C Antibody H3 histone family, member D Antibody H3 histone family, member F Antibody H3 histone family, member H Antibody H3 histone family, member I Antibody H3 histone family, member J Antibody H3 histone family, member K Antibody H3 histone family, member L Antibody H3 histone family, member T Antibody H3 histone, family 3A Antibody H3 i Antibody H3 j Antibody H3 k Antibody H3 l Antibody H3.1 Antibody H3.3A Antibody H3/A Antibody H3/b Antibody H3/c Antibody H3/d Antibody h3/f Antibody H3/h Antibody H3/i Antibody H3/j Antibody H3/k Antibody H3/l Antibody H3/t Antibody H31_HUMAN Antibody H33_HUMAN Antibody H3F1K Antibody H3F3 Antibody H3F3A Antibody H3f3b Antibody H3FA Antibody H3FB Antibody H3FC Antibody H3FD Antibody H3FF Antibody H3FH Antibody H3FI Antibody H3FJ Antibody H3FK Antibody H3FL Antibody HIST1 cluster, H3A Antibody HIST1 cluster, H3B Antibody HIST1 cluster, H3C Antibody HIST1 cluster, H3D Antibody HIST1 cluster, H3F Antibody HIST1 cluster, H3G Antibody HIST1 cluster, H3H Antibody HIST1 cluster, H3I Antibody HIST1 cluster, H3J Antibody Hist1h3a Antibody HIST1H3B Antibody HIST1H3C Antibody HIST1H3D Antibody HIST1H3E Antibody HIST1H3F Antibody HIST1H3G Antibody HIST1H3H Antibody HIST1H3I Antibody HIST1H3J Antibody HIST3H3 Antibody HIST3HA Antibody histone 1, H3a Antibody Histone 1, H3b Antibody Histone 1, H3c Antibody Histone 1, H3d Antibody Histone 1, H3e Antibody Histone 1, H3f Antibody Histone 1, H3g Antibody Histone 1, H3h Antibody Histone 1, H3i Antibody Histone 1, H3j Antibody Histone 3, H3 Antibody histone cluster 1 H3 family member a Antibody histone cluster 1 H3 family member b Antibody histone cluster 1 H3 family member c Antibody histone cluster 1 H3 family member d Antibody histone cluster 1 H3 family member e Antibody histone cluster 1 H3 family member f Antibody histone cluster 1 H3 family member g Antibody histone cluster 1 H3 family member h Antibody histone cluster 1 H3 family member i Antibody histone cluster 1 H3 family member j Antibody Histone cluster 1, H3a Antibody Histone cluster 1, H3b Antibody Histone cluster 1, H3c Antibody Histone cluster 1, H3d Antibody Histone cluster 1, H3e Antibody Histone cluster 1, H3f Antibody Histone cluster 1, H3g Antibody Histone cluster 1, H3i Antibody Histone cluster 1, H3j Antibody Histone gene cluster 1, H3 histone family, member A Antibody Histone gene cluster 1, H3 histone family, member B Antibody Histone gene cluster 1, H3 histone family, member C Antibody Histone gene cluster 1, H3 histone family, member D Antibody Histone gene cluster 1, H3 histone family, member F Antibody Histone gene cluster 1, H3 histone family, member G Antibody Histone gene cluster 1, H3 histone family, member H Antibody Histone gene cluster 1, H3 histone family, member I Antibody Histone gene cluster 1, H3 histone family, member J Antibody Histone gene cluster 1, H3A Antibody Histone gene cluster 1, H3B Antibody Histone gene cluster 1, H3C Antibody Histone gene cluster 1, H3D Antibody Histone gene cluster 1, H3E Antibody Histone gene cluster 1, H3F Antibody Histone gene cluster 1, H3G Antibody Histone gene cluster 1, H3H Antibody Histone gene cluster 1, H3I Antibody Histone gene cluster 1, H3J Antibody Histone H 3 Antibody Histone H3 Antibody Histone H3 3 pseudogene Antibody Histone H3 Citrullated Antibody Histone H3.1 Antibody Histone H3.1t Antibody Histone H3.2 Antibody Histone H3.3 Antibody Histone H3.3C Antibody Histone H3.5 Antibody Histone H3/a Antibody Histone H3/b Antibody Histone H3/c Antibody Histone H3/d Antibody Histone H3/f Antibody Histone H3/h Antibody Histone H3/i Antibody Histone H3/j Antibody Histone H3/k Antibody Histone H3/l Antibody Histone H3/m Antibody Histone H3/o Antibody
Information:	Target information shown above is from the UniProt Consortium.