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Anti-VEGF-A Antibody

品牌：Antibodies

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规格：50µl

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Anti-VEGF-A Antibody

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Overview

Name:	Anti-VEGF-A Antibody See all VEGFA primary antibodies
Description:	Rabbit polyclonal antibody to VEGF-A
Specificity:	VEGFA pAb detects endogenous levels of VEGFA protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant full length Human VEGF-A.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 27 kDa (VEGF206); 45 kDa (L-VEGF206); ~ 15-44 kDa (Others Isoform)
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.

Target

Function:	Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth.
Tissue Specificity:	Isoform VEGF189, isoform VEGF165 and isoform VEGF121 are widely expressed. Isoform VEGF206 and isoform VEGF145 are not widely expressed. A higher level expression seen in pituitary tumors as compared to the pituitary gland.
Involvement in Disease:	Microvascular complications of diabetes 1: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic *****s. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.
Sequence Similarities:	Belongs to the PDGF/VEGF growth factor family.
Cellular Location:	Secreted. VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a signicant proportion remains cell-associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin.
Database Links:	Entrez Gene: 7422?Human Entrez Gene: 22339?Mouse Entrez Gene: 83785?Rat Omim: 192240?Human SwissProt: P15692?Human SwissProt: Q00731?Mouse SwissProt: P16612?Rat Unigene: 73793?Human Unigene: 282184?Mouse Unigene: 1923?Rat
Synonyms:	Folliculostellate cell-derived growth factor Antibody Glioma-derived endothelial cell mitogen Antibody MGC70609 Antibody MVCD1 Antibody vascular endothelial growth factor Antibody Vascular endothelial growth factor A Antibody vascular endothelial growth factor A121 Antibody vascular endothelial growth factor A165 Antibody Vascular permeability factor Antibody Vegf Antibody VEGF A Antibody VEGF-A Antibody VEGF120 Antibody VEGFA Antibody VEGFA_HUMAN Antibody VPF Antibody
Information:	Target information shown above is from the UniProt Consortium.