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Anti-FOXC1 Antibody

品牌：Antibodies

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规格：100µg

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应用：

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Anti-FOXC1 Antibody

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Overview

Name:	Anti-FOXC1 Antibody See all FOXC1 primary antibodies
Description:	Goat polyclonal antibody to FOXC1.
Applications:	ELISA, WB
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to Human FOXC1 (C terminal).
Sequence:	RTSGAFVYDCSKF
Host:	Goat
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	100 µg at 0.5 mg/ml.
Product Form:	Liquid
Formulation:	Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Binding of FREAC-3 and FREAC-4 to their cognate sites results in bending of the DNA at an angle of 80-90 degrees. Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye.
Tissue Specificity:	Expressed in all tissues and cell lines examined.
Involvement in Disease:	Axenfeld-Rieger syndrome 3: An autosomal dominant disorder of morphogenesis that results in abnormal development of the anterior segment of the eye, and results in blindness from glaucoma in approximately 50% of affected individuals. Features include posterior corneal embryotoxon, prominent Schwalbe line and iris adhesion to the Schwalbe line, hypertelorism, hypodontia, sensorineural deafness, redundant periumbilical skin, and cardiovascular defects such as patent ductus arteriosus and atrial septal defect. When associated with tooth anomalies, the disorder is known as Rieger syndrome. Iridogoniodysgenesis anomaly: Autosomal dominant phenotype characterized by iris hypoplasia, goniodysgenesis, and juvenile glaucoma. Peters anomaly: Consists of a central corneal leukoma, absence of the posterior corneal stroma and Descemet membrane, and a variable degree of iris and lenticular attachments to the central aspect of the posterior cornea.
Cellular Location:	Nucleus.
Database Links:	Entrez Gene: 2296 Human GenBank: NP_001444 Human Omim: 601090 Human SwissProt: Q12948 Human Unigene: 348883 Human
Synonyms:	ARA Antibody FKH L7 Antibody FKHL 7 Antibody FKHL7 Antibody Forkhead (Drosophila) like 7 Antibody Forkhead box C1 Antibody Forkhead box protein C1 Antibody Forkhead drosophila homolog like 7 Antibody Forkhead like 7 Antibody Forkhead related activator 3 Antibody Forkhead related protein FKHL7 Antibody Forkhead related transcription factor 3 Antibody Forkhead-related protein FKHL7 Antibody Forkhead-related transcription factor 3 Antibody FOX C1 Antibody FOXC 1 Antibody FOXC1 Antibody FOXC1_HUMAN Antibody FREAC 3 Antibody FREAC-3 Antibody FREAC3 Antibody IGDA Antibody IHG 1 Antibody IHG1 Antibody IRID 1 Antibody IRID1 Antibody Iridogoniodysgenesis type 1 Antibody Myeloid factor delta Antibody
Information:	Target information shown above is from the UniProt Consortium.