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Anti-CD146 Antibody

品牌：Antibodies

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规格：100µg

货期：

应用：

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Anti-CD146 Antibody

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Overview

Name:	Anti-CD146 Antibody See all CD146 primary antibodies
Description:	Mouse monoclonal (P1H12) antibody to CD146.
Specificity:	The mouse monoclonal antibody P1H12 recognizes CD146, a 118 kDa transmembrane glycoprotein expressed on epithelial and endothelial cells, fibroblasts, multipotent mesenchymal stromal cells, melanoma cells, activated T cells and activated keratinocytes.
Applications:	FC, IP, WB, IHC-P, IHC-Fr, ICC
Reactivity:	Human, Mouse, Dog, Rabbit
Immunogen:	Cultured human umbilical cells.
Host:	Mouse
Clonality:	Monoclonal
Clone:	P1H12
Isotype:	IgG1
Conjugate:	Unconjugated
Purification:	Protein A chromatography.
Concentration:	1 mg/ml
Purity:	> 95% (by SDS-PAGE)
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.4, with 15mM Sodium Azide.
Storage:	Store at 2-8°C.

Target

Function:	Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration (By similarity).
Tissue Specificity:	Detected in melanoma cell lines.
Cellular Location:	Membrane.
Database Links:	Entrez Gene: 4162?Human Entrez Gene: 84004?Mouse Omim: 155735?Human SwissProt: P43121?Human SwissProt: Q8R2Y2?Mouse Unigene: 599039?Human Unigene: 275003?Mouse
Synonyms:	A32 antigen Antibody CD 146 Antibody CD146 Antibody CD146 antigen Antibody Cell surface glycoprotein MUC18 Antibody Cell surface glycoprotein P1H12 Antibody Gicerin Antibody Mcam Antibody Melanoma adhesion molecule Antibody Melanoma associated antigen A32 Antibody Melanoma associated antigen MUC18 Antibody Melanoma associated glycoprotein MUC18 Antibody Melanoma cell adhesion molecule Antibody Melanoma-associated antigen A32 Antibody Melanoma-associated antigen MUC18 Antibody MelCAM Antibody MUC 18 Antibody MUC18 Antibody MUC18_HUMAN Antibody S endo 1 Antibody S endo 1 endothelial associated antigen Antibody S-endo 1 endothelial-associated antigen Antibody
Information:	Target information shown above is from the UniProt Consortium.