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Anti-Nrf2 (L593) Antibody

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规格：50µl

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Anti-Nrf2 (L593) Antibody

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Overview

Name:	Anti-Nrf2 (L593) Antibody See all Nrf2 primary antibodies
Description:	Rabbit polyclonal antibody to Nrf2 (L593)
Specificity:	Nrf2/NFE2L2 (L593) pAb detects endogenous levels of Nrf2/NFE2L2 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 560-621 of Human Nrf2.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 68 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.
Tissue Specificity:	Widely expressed. Highest expression in ***** muscle, kidney, lung, liver and in fetal muscle.
Sequence Similarities:	Belongs to the bZIP family. CNC subfamily.
Post-Translational Modification:	Phosphorylation of Ser-40 by PKC in response to oxidative stress dissociates NFE2L2 from its cytoplasmic inhibitor KEAP1, promoting its translocation into the nucleus.
Cellular Location:	Cytoplasm > Cytosol. Nucleus. Cytosolic under unstressed conditions, translocates into the nucleus upon induction by electrophilic agents.
Database Links:	Entrez Gene: 4780?Human Entrez Gene: 18024?Mouse Entrez Gene: 83619?Rat Omim: 600492?Human SwissProt: Q16236?Human SwissProt: Q60795?Mouse SwissProt: O54968?Rat Unigene: 744006?Human Unigene: 1025?Mouse Unigene: 10867?Rat
Synonyms:	erythroid derived 2 Antibody HEBP1 Antibody like 2 Antibody NF E2 related factor 2 Antibody NF-E2-related factor 2 Antibody NF2L2_HUMAN Antibody NFE2 related factor 2 Antibody NFE2-related factor 2 Antibody Nfe2l2 Antibody Nrf 2 Antibody Nrf2 Antibody Nuclear factor Antibody Nuclear factor (erythroid derived 2) like 2 Antibody nuclear factor erythroid 2 like 2 Antibody Nuclear factor erythroid 2 related factor 2 Antibody Nuclear factor erythroid 2-related factor 2 Antibody Nuclear factor erythroid derived 2 like 2 Antibody
Information:	Target information shown above is from the UniProt Consortium.