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Anti-PIM2 Antibody

品牌：Antibodies

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规格：100µg

货期：

应用：

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Anti-PIM2 Antibody

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Overview

Name:	Anti-PIM2 Antibody See all PIM2 primary antibodies
Description:	Goat polyclonal antibody to PIM2.
Applications:	ELISA, WB
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to Human PIM2 (internal region).
Sequence:	C-PPGGKDREAFEAE
Host:	Goat
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	100 µg at 0.5 mg/ml.
Product Form:	Liquid
Formulation:	Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity. The stabilization of MYC exerted by PIM2 might explain partly the strong synergism between these 2 oncogenes in tumorigenesis. Regulates cap-dependent protein translation in a mammalian target of rapamycin complex 1 (mTORC1)-independent manner and in parallel to the PI3K-Akt pathway. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Promotes cell survival in response to a variety of proliferative signals via positive regulation of the I-kappa-B kinase/NF-kappa-B cascade; this process requires phosphorylation of MAP3K8/COT. Promotes growth factor-independent proliferation by phosphorylation of cell cycle factors such as CDKN1A and CDKN1B. Involved in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate.
Tissue Specificity:	Highly expressed in hematopoietic tissues, in leukemic and lymphoma cell lines, testis, small intestine, colon and colorectal adenocarcinoma cells. Weakly expressed in normal liver, but highly expressed in hepatocellular carcinoma tissues.
Sequence Similarities:	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
Post-Translational Modification:	Autophosphorylated.
Database Links:	Entrez Gene: 11040 Human Omim: 300295 Human SwissProt: Q9P1W9 Human Unigene: 726382 Human
Synonyms:	OTTHUMP00000025825 Antibody Pim 2 oncogene Antibody Pim 2h Antibody Pim-2h Antibody PIM2 Antibody PIM2 Oncogene Antibody Pim2h Antibody PIM2_HUMAN Antibody Proto Oncogene PIM2 Antibody Proto-oncogene Pim-2 (serine threonine kinase) Antibody Serine/threonine kinase PIM2 Antibody Serine/threonine-protein kinase Pim-2 Antibody
Information:	Target information shown above is from the UniProt Consortium.