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Anti-Cytokeratin 14 Antibody

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Anti-Cytokeratin 14 Antibody

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Overview

Name:	Anti-Cytokeratin 14 Antibody See all Cytokeratin 14 primary antibodies
Description:	Mouse monoclonal (LL002) antibody to Cytokeratin 14.
Specificity:	Human cytokeratin 14.
Applications:	IHC
Reactivity:	Human
Immunogen:	C-terminal 15-AA peptide of cytokeratin 14 conjugated to thyroglobulin.
Host:	Mouse
Clonality:	Monoclonal
Clone:	LL002
Isotype:	IgG3
Conjugate:	Unconjugated
Concentration:	40 μg/ml
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.3, with 0.09% Sodium Azide.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
General Notes:	This antibody labels the basal layer of stratifying squamous and non-squamous epithelia. The staining pattern is cytoplasmic. It recognises basal cell carcinomas and squamous cell carcinomas.

Target

Function:	The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro.
Tissue Specificity:	Detected in the basal layer, lowered within the more apically located layers specifically in the stratum spinosum, stratum granulosum but is not detected in stratum corneum. Strongly expressed in the outer root sheath of anagen follicles but not in the germinative matrix, inner root sheath or hair. Found in keratinocytes surrounding the club hair during telogen.
Involvement in Disease:	Epidermolysis bullosa simplex, Dowling-Meara type: A severe form of intraepidermal epidermolysis bullosa characterized by generalized herpetiform blistering, milia formation, dystrophic nails, and mucous membrane involvement. Epidermolysis bullosa simplex, Weber-Cockayne type: A form of intraepidermal epidermolysis bullosa characterized by blistering limited to palmar and plantar areas of the skin. Epidermolysis bullosa simplex, Koebner type: A form of intraepidermal epidermolysis bullosa characterized by generalized skin blistering. The phenotype is not fundamentally distinct from the Dowling-Meara type, although it is less severe. Epidermolysis bullosa simplex, autosomal recessive 1: An intraepidermal epidermolysis bullosa characterized by localized blistering on the dorsal, lateral and plantar surfaces of the feet. Naegeli-Franceschetti-Jadassohn syndrome: A rare autosomal dominant form of ectodermal dysplasia. The cardinal features are absence of dermatoglyphics (fingerprints), reticular cutaneous hyperpigmentation (starting at about the age of 2 years without a preceding inflammatory stage), palmoplantar keratoderma, hypohidrosis with diminished sweat gland function and discomfort provoked by heat, nail dystrophy, and tooth enamel defects. Dermatopathia pigmentosa reticularis: A rare ectodermal dysplasia characterized by lifelong persistent reticulate hyperpigmentation, non-cicatricial alopecia, and nail dystrophy. Variable features include adermatoglyphia, hypohidrosis or hyperhidrosis, and palmoplantar hyperkeratosis.
Sequence Similarities:	Belongs to the intermediate filament family.
Post-Translational Modification:	A disulfide bond is formed between rather than within filaments and promotes the formation of a keratin filament cage around the nucleus.
Cellular Location:	Cytoplasm. Nucleus. Expressed in both as a filamentous pattern.
Database Links:	Entrez Gene: 3861?Human Omim: 148066?Human SwissProt: P02533?Human Unigene: 654380?Human
Synonyms:	CK 14 Antibody CK-14 Antibody ck14 Antibody Cytokeratin 14 Antibody Cytokeratin-14 Antibody Cytokeratin14 Antibody Dowling Meara Antibody EBS3 Antibody EBS4 Antibody Epidermolysis bullosa simplex Antibody K14 Antibody K1C14_HUMAN Antibody Keratin Antibody Keratin 14 Antibody Keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner) Antibody Keratin type I cytoskeletal 14 Antibody Keratin, type I cytoskeletal 14 Antibody Keratin-14 Antibody Keratin14 Antibody Koebner Antibody Krt 14 Antibody Krt14 Antibody NFJ Antibody OTTHUMP00000164624 Antibody type I cytoskeletal 14 Antibody
Information:	Target information shown above is from the UniProt Consortium.