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Anti-Bcl-2 (D64) Antibody

品牌：Antibodies

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规格：50µl

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Anti-Bcl-2 (D64) Antibody

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Overview

Name:	Anti-Bcl-2 (D64) Antibody See all Bcl-2 primary antibodies
Description:	Rabbit polyclonal antibody to Bcl-2 (D64)
Specificity:	Bcl-2 (D64) pAb detects endogenous levels of Bcl-2 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 31-80 of Human Bcl-2.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 26 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).
Tissue Specificity:	Expressed in a variety of tissues.
Sequence Similarities:	Belongs to the Bcl-2 family.
Post-Translational Modification:	Phosphorylation/dephosphorylation on Ser-70 regulates anti-apoptotic activity. Growth factor-stimulated phosphorylation on Ser-70 by PKC is required for the anti-apoptosis activity and occurs during the G2/M phase of the cell cycle. In the absence of growth factors, BCL2 appears to be phosphorylated by other protein kinases such as ERKs and stress-activated kinases. Phosphorylated by MAPK8/JNK1 at Thr-69, Ser-70 and Ser-87, wich stimulates starvation-induced autophagy. Dephosphorylated by protein phosphatase 2A (PP2A) (By similarity).
Cellular Location:	Mitochondrion outer membrane. Nucleus membrane. Endoplasmic reticulum membrane.
Database Links:	Entrez Gene: 596?Human Entrez Gene: 12043?Mouse Entrez Gene: 24224?Rat Omim: 151430?Human SwissProt: P10415?Human SwissProt: P10417?Mouse SwissProt: P49950?Rat Unigene: 150749?Human Unigene: 257460?Mouse Unigene: 9996?Rat
Synonyms:	Apoptosis regulator Bcl 2 Antibody Apoptosis regulator Bcl-2 Antibody Apoptosis regulator Bcl2 Antibody AW986256 Antibody B cell CLL/lymphoma 2 Antibody B cell leukemia/lymphoma 2 Antibody Bcl-2 Antibody Bcl2 Antibody BCL2_HUMAN Antibody C430015F12Rik Antibody D630044D05Rik Antibody D830018M01Rik Antibody Leukemia/lymphoma, B-cell, 2 Antibody Oncogene B-cell leukemia 2 Antibody PPP1R50 Antibody Protein phosphatase 1, regulatory subunit 50 Antibody
Information:	Target information shown above is from the UniProt Consortium.