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Anti-GAPDH (1A6) Antibody

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规格：50µl

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Anti-GAPDH (1A6) Antibody

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Overview

Name:	Anti-GAPDH (1A6) Antibody See all GAPDH primary antibodies
Description:	Mouse monoclonal antibody to GAPDH (1A6)
Specificity:	GAPDH (1A6) mAb detects endogenous levels of GAPDH protein.
Applications:	ELISA, WB, IHC, IF
Reactivity:	Human, Mouse, Rabbit, Frog, Fish, Chicken, Rat
Immunogen:	Recombinant full length Human GAPDH.
Host:	Mouse
Clonality:	Monoclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 36 kDa
Purity:	The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.

Target

Function:	Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (By similarity).
Tissue Specificity:	High levels in skeletal muscle and heart, low levels in liver, brain, and kidney.
Sequence Similarities:	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
Post-Translational Modification:	S-nitrosylation of Cys-150 leads to interaction with SIAH1, followed by translocation to the nucleus. The effect of S-nitrosylation on enzymatic activity is unclear: according to some authors, it inhibits enzymatic activity and increases endogenous ADP-ribosylation, inhibiting the enzyme in a non-reversible manner (PubMed:8626764). According to others, it does not affect glycolysis (PubMed:15951807). ADP-ribosylation is likely to be a pathophysiological event associated with inhibition of gluconeogenesis. S-nitrosylation of Cys-245 is induced by interferon-gamma and LDL(ox) implicating the iNOS-S100A8/9 transnitrosylase complex and seems to prevent interaction with phosphorylated RPL13A and to interfere with GAIT complex activity (By similarity).
Cellular Location:	Cytoplasm > Cytosol. Cytoplasm > Cytoskeleton. Nucleus. Translocates to the nucleus following S-nitrosylation and interaction with SIAH1, which contains a nuclear localization signal. Colocalizes with CHP1 to small punctate structures along the microtubules tracks.
Database Links:	Entrez Gene: 374193?Chicken Entrez Gene: 2597?Human Entrez Gene: 100042025?Mouse Entrez Gene: 14433?Mouse Entrez Gene: 100009074?Rabbit Entrez Gene: 24383?Rat Entrez Gene: 685186?Rat Omim: 138400?Human SwissProt: P00356?Chicken SwissProt: P04406?Human SwissProt: P16858?Mouse SwissProt: P46406?Rabbit SwissProt: P04797?Rat Unigene: 544577?Human Unigene: 592355?Human Unigene: 598320?Human Unigene: 304088?Mouse Unigene: 309092?Mouse Unigene: 317779?Mouse Unigene: 343110?Mouse Unigene: 392463?Mouse Unigene: 392480?Mouse Unigene: 414470?Mouse Unigene: 458138?Mouse Unigene: 458416?Mouse Unigene: 475698?Mouse Unigene: 129558?Rat Unigene: 91450?Rat
Synonyms:	38 kDa BFA-dependent ADP-ribosylation substrate Antibody aging associated gene 9 protein Antibody Aging-associated gene 9 protein Antibody BARS-38 Antibody cb609 Antibody EC 1.2.1.12 Antibody Epididymis secretory sperm binding protein Li 162eP Antibody G3PD Antibody G3PDH Antibody G3P_HUMAN Antibody GAPD Antibody GAPDH Antibody Glyceraldehyde 3 phosphate dehydrogenase Antibody Glyceraldehyde-3-phosphate dehydrogenase Antibody HEL S 162eP Antibody HEL-S-162eP Antibody KNC-NDS6 Antibody MGC102544 Antibody MGC102546 Antibody MGC103190 Antibody MGC103191 Antibody MGC105239 Antibody MGC127711 Antibody MGC88685 Antibody OCAS, p38 component Antibody OCT1 coactivator in S phase, 38-KD component Antibody peptidyl cysteine S nitrosylase GAPDH Antibody Peptidyl-cysteine S-nitrosylase GAPDH Antibody wu:fb33a10 Antibody
Information:	Target information shown above is from the UniProt Consortium.