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Anti-Alpha-Actin Antibody

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Anti-Alpha-Actin Antibody

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Overview

Name:	Anti-Alpha-Actin Antibody See all alpha-Actin primary antibodies
Description:	Mouse monoclonal (1A4) antibody to Alpha-Actin.
Specificity:	Alpha-Actin, smooth muscle.
Applications:	IHC
Reactivity:	Human
Immunogen:	Synthetic N-terminal decapeptide of smooth muscle Alpha-Actin.
Host:	Mouse
Clonality:	Monoclonal
Clone:	1A4
Isotype:	IgG2a
Conjugate:	Unconjugated
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.3, with 0.09% Sodium Azide.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
General Notes:	This antibody detects alpha-actin of smooth muscle origin, thus it is suitable to distinguish smooth muscle cells from cells of sarcomeric origin. It may also be used for differentiation from fibroblast actin (F-actin).

Target

Function:	Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Involvement in Disease:	Nemaline myopathy 3: A form of nemaline myopathy. Nemaline myopathies are muscular disorders characterized by muscle weakness of varying severity and onset, and abnormal thread-like or rod-shaped structures in muscle fibers on histologic examination. Myopathy, actin, congenital, with excess of thin myofilaments: A congenital muscular disorder characterized at histological level by areas of sarcoplasm devoid of normal myofibrils and mitochondria, and replaced with dense masses of thin filaments. Central cores, rods, ragged red fibers, and necrosis are absent. Myopathy, congenital, with fiber-type disproportion: A genetically heterogeneous disorder in which there is relative hypotrophy of type 1 muscle fibers compared to type 2 fibers on skeletal muscle biopsy. However, these findings are not specific and can be found in many different myopathic and neuropathic conditions. Myopathy, scapulohumeroperoneal: An autosomal dominant muscular disorder characterized by progressive muscle weakness with initial scapulo-humeral-peroneal and distal distribution. Over time, muscle weakness progresses to proximal muscle groups. Clinical characteristics include scapular winging, mild lower facial weakness, foot drop due to foot eversion and dorsiflexion weakness, and selective muscle atrophy. Age at onset and disease progression are variable.
Sequence Similarities:	Belongs to the actin family.
Post-Translational Modification:	Oxidation of Met-46 and Met-49 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization (By similarity).
Cellular Location:	Cytoplasm > Cytoskeleton.
Database Links:	Entrez Gene: 58?Human Omim: 102610?Human SwissProt: P68133?Human Unigene: 1288?Human
Synonyms:	a actin Antibody ACTA Antibody ACTA1 Antibody Actin Antibody Actin alpha skeletal muscle Antibody actin, alpha 1, skeletal muscle Antibody actin, alpha 1, skeletal muscle 1 Antibody Actin, alpha skeletal muscle Antibody actina Antibody actine Antibody ACTS_HUMAN Antibody aktin Antibody Alpha Actin 1 Antibody alpha skeletal muscle Antibody Alpha skeletal muscle Actin Antibody alpha-actin Antibody Alpha-actin-1 Antibody ASMA Antibody CFTD Antibody CFTD1 Antibody CFTDM Antibody MPFD Antibody NEM1 Antibody NEM2 Antibody NEM3 Antibody nemaline myopathy type 3 Antibody
Information:	Target information shown above is from the UniProt Consortium.