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P792 – Vistarem® (Gadomelitol)

   

P792 – Vistarem® (Gadomelitol)

470.00 

Category: Preclinical MRI probes

Description

Catalogue Number P792
Description Monogadolinated MRI blood-pool agent of 5 nm diameter. Pharmacokinetics and biodistribution profiles consistent with a rapid-clearance blood-pool agent (RCBPA): mainly excreted by glomerular filtration with limited diffusion across normal endothelium
Main Applications DCE-MRI (Ktrans modeling, tumoral characterization / treatment follow up), high resolution contrast-enhanced MR angiography (MRA), myocardial perfusion, arthrography, myocardial perfusion and viability
Molecular characteristics
–  Hydrodynamic size: diameter is approximately 5 nm (compared to 1 nm for Gd-DOTA)
–  Gd content: 1 atom per particle
–  Molecular weight: 6.5 kDa
–  Recommended dose: 50 μmol/kg = 2.5 μL/g
Example: for a 30g body weight mouse, injection volume is 75 μL
– Relaxivities (s-1.mM-1, 37°C, 4% Human Albumin Serum)
Bo(T)

1.5

2.35

3.0

4.7

7.0

r1

27

15

12

7

5

r2

68

67

68

66

63

Characteristics of the vial

–  Concentration: [Gd] = 20 mmol/L
–  Volume: 450 μL (5 mice dose approx.)
–  Other animal species: please contact us

Storage Need to be stored at 4°C in a closed vial and away from light
Notes For in vitro or animal use only
Selected publications [1] Ceelen W et al. Br J Cancer 2007 [2] Dewey et al.Investigative Radiology 2004 [3] Watrin Pinzano A et al. Biomed Mater Eng 2008 [4] Ruehm et al. Magnetic Resonance in Medicine 2002 [5] Dirksen MS et al. Eur Radiol 2003 [6] Herborn CU et al. Invest Rad

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