P846 – LDA (Low Diffusable contrast Agent)

–  Gd content: one Gd atom per molecule

–  Hydrodynamic size: diameter is 2-3 nm

–  Molecular weight: 3.5 kDa

–  Dose: due to high relaxivity of P846, the injected dose is lower than that of conventional contrast agent like Gd-DOTA

Recommended dose: 50 μmol/kg = 2.5 μL/g

Example: for a 30g body weight mouse, injection volume is 75 μL

–  Relaxivities (s-1.mM-1, 37°C, Human Albumin Serum 4%)

–  In vitro quantification techniques: P846 is a Gd-based contrast agent. Gd can be dosed by ICP-AES or ICP-MS. Another way to quantify Gd chelates is by T1 or T2 relaxometry, with assumption of r1 or r2.

–  Volume: 450 μL (5 mice dose approx.)

–  Other animal species: please contact us