HomePreclinical MRI probesP00449 – Gd-DOTA P00449 – Gd-DOTA 210.00 € Category: Preclinical MRI probes

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P00449 – Gd-DOTA

210.00 €

Category: Preclinical MRI probes

Description

Catalogue Number

P00449

Description

Ionic macrocyclic gadolinium complex of DOTA designed for MRI imaging. Its parametric proprieties increase contrast enhancement in MRI. Freely excreted by the kidneys and very inert biologically

Main Applications

Detection of brain tumor, rachis pathology, whole body pathology (including angiography), osteo-articular imaging, brain perfusion, DCE – MRI

Molecular characteristics

– Macrocyclic and ionic Gd-based chelate

– Hydrodynamic size: 1 nm

– Molecular weight: 560 Da

– Recommended dose: 100 μmol/kg = 2.5 μL/g

– Relaxivities (s-1.mM-1, precision ±10%, 37°C, HSA 4%) [1]

Bo(T)	0.47	1.5	2.35	3.0	4.7	7.0
r1	3.5	3.5	3.4	3.4	3.3	3.0
r2	3.7	4.2	4.2	4.2	4.1	4.0

– Quantitative techniques: ICP-AES, ICP-MS, relaxometry…

Characteristics of the vial

– Concentration: [Gd] = 40 mmol/L
– Volume: 450 μL (5 mice dose approx.)
– Other animal species: contact us

Storage

Need to be stored at ambient temperature in a closed vial

Notes

For in vitro or animal use only

Selected publications

1] Unpublished Guerbet Data [2] Idee et al., Fundam Clin Pharmacol., 2006 [3] Van der Elst; ISMRM 2013 [4] Lefevre et al., Radiology 2011 [5] Ruehm et al, MRM 2000