HomePreclinical MRI probesP792 – Vistarem® (Gadomelitol) P792 – Vistarem® (Gadomelitol) 470.00 € Category: Preclinical MRI probes

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P792 – Vistarem® (Gadomelitol)

470.00 €

Category: Preclinical MRI probes

Description

Catalogue Number

P792

Description

Monogadolinated MRI blood-pool agent of 5 nm diameter. Pharmacokinetics and biodistribution profiles consistent with a rapid-clearance blood-pool agent (RCBPA): mainly excreted by glomerular filtration with limited diffusion across normal endothelium

Main Applications

DCE-MRI (Ktrans modeling, tumoral characterization / treatment follow up), high resolution contrast-enhanced MR angiography (MRA), myocardial perfusion, arthrography, myocardial perfusion and viability

Molecular characteristics

– Hydrodynamic size: diameter is approximately 5 nm (compared to 1 nm for Gd-DOTA)
– Gd content: 1 atom per particle

– Molecular weight: 6.5 kDa

– Recommended dose: 50 μmol/kg = 2.5 μL/g

Example: for a 30g body weight mouse, injection volume is 75 μL

– Relaxivities (s-1.mM-1, 37°C, 4% Human Albumin Serum)

Bo(T)	1.5	2.35	3.0	4.7	7.0
r1	27	15	12	7	5
r2	68	67	68	66	63

Characteristics of the vial

– Concentration: [Gd] = 20 mmol/L
– Volume: 450 μL (5 mice dose approx.)
– Other animal species: please contact us

Storage

Need to be stored at 4°C in a closed vial and away from light

Notes

For in vitro or animal use only

Selected publications

[1] Ceelen W et al. Br J Cancer 2007 [2] Dewey et al.Investigative Radiology 2004 [3] Watrin Pinzano A et al. Biomed Mater Eng 2008 [4] Ruehm et al. Magnetic Resonance in Medicine 2002 [5] Dirksen MS et al. Eur Radiol 2003 [6] Herborn CU et al. Invest Rad